کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3053475 1580005 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neurological complications after gamma-knife radiosurgery for hypothalamic hamartoma
ترجمه فارسی عنوان
عوارض عصبی پس از رادیوجراحی گاما ـ چاقو برای هوماترم هیپوتالامیک
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی


• The Gamma-knife technique is an effective option for the treatment of hypothalamic hamartomas.
• Radiological changes, side effects and neurological complications are uncommon consequences.
• We report radiological resolution of a hypothalamic hamartoma as well as neurological complications after Gamma-knife surgery.
• If a patient presents neurological symptoms, possible complications of this type of surgery must be taken into account.

BackgroundThe Gamma-knife technique is a safe and effective option for the treatment of hypothalamic hamartomas that produce epileptic seizures refractory to medical treatment and/or serious behavioral disorders. After this type of radiosurgery, an adequate symptomatic control is normally achieved, with notable decrease or even disappearance of the seizures. Radiological changes, such as a decrease in the size of the tumor or adjacent edema secondary to non-necrotizing radioinduced inflammatory reaction are unusual consequences. Side effects and neurological complications are also rare events.Case presentationThis report describes an unusual case of complete radiological resolution of a hypothalamic hamartoma as well as neurological complications after Gamma-knife surgery (receiving 13 Gy to the 85% isodose line, 1 cm3 of tumor volume) in a 8-year-old boy who suffered from severe refractory seizures. After radiosurgery, the patient experienced a notable improvement in his symptoms, achieving seizure cessation within 3 months. However, 4 months after the procedure he presented drowsiness, fever and decreased level of consciousness due to a direct effect on the hypothalamus with local and regional edema secondary to the radiosurgery that was performed. He was successfully treated with corticosteroids (with a total duration of 11 months), and twelve months after the surgery, complete disappearance of both the nodular lesion and the secondary edema was observed. The patient remains seizure-free in the last 16 months, with remarkable changes in his behavior.ConclusionsThe present case shows that complete radiological resolution of a hypothalamic hamartoma after Gamma-knife technique is unusual but possible, without long-term neurological consequences. Nevertheless, despite its low incidence, if a patient presents neurological symptoms, primarily during the first year after intervention, possible complications of this type of surgery must be taken into account.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Paediatric Neurology - Volume 20, Issue 5, September 2016, Pages 745–749
نویسندگان
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