کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
3053478 1580005 2016 3 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Severe pneumonia by Mycoplasma as an adverse event of everolimus therapy in patients with tuberous sclerosis complex
ترجمه فارسی عنوان
پنومونی شدید با مایکوپلاسما به عنوان یک رویداد نامطلوب everolimus تراپی با کمپلکس توبروس اسکلروز
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی


• The safety of everolimus treatment in young children has not yet been well reported.
• In most cases, adverse events are self-limiting and well tolerated overall.
• We report two cases of severe bacterial infection by Mycoplasma in children.
• The etiological diagnosis was achieved by PCR rather than serology.

BackgroundEpilepsy is one of the most common symptoms in Tuberous Sclerosis Complex (TSC), appearing mainly in the first year of life and often resistant to therapy. Several studies have demonstrated the effectiveness of everolimus but its safety in children has not yet been well reported. We present two cases of severe pneumonia caused by Mycoplasma in two children receiving everolimus for epilepsy secondary to TSC.Study casesBoth patients were admitted to the PICU for severe pneumonia with pleural effusion. One of them needed support with high concentration of oxygen and broad spectrum antibiotics and the other developed a septic shock with acute respiratory distress needing mechanical ventilation, vasoactive drugs, pleural drainage and broad-spectrum antibiotics. Everolimus was discontinued and in both patients Mycoplasma pneumoniae was identified by PCR. Both patients were discharged without sequelae.ConclusionEverolimus therapy for epilepsy in the context of TCS could be associated, as in these two cases, with severe bacterial infection by Mycoplasma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Paediatric Neurology - Volume 20, Issue 5, September 2016, Pages 758–760
نویسندگان
, , , , , , ,