کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3074811 1580955 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effective connectivity of the seizure onset zone and ictal perfusion changes in amygdala kindled rhesus monkeys
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
The effective connectivity of the seizure onset zone and ictal perfusion changes in amygdala kindled rhesus monkeys
چکیده انگلیسی


• Amygdala kindling in rhesus monkeys models epileptogenesis in MTLE
• Interictal EM-fMRI reveals the network connected to the kindled amygdala.
• Ictal SPECT perfusion imaging shows the brain network during seizures.
• The perfusion changes partially overlap with the connected areas.
• Seizure activity appears to spread, to a large extent, via these connected areas.

Epileptic seizures are network-level phenomena. Hence, epilepsy may be regarded as a circuit-level disorder that cannot be understood outside this context. Better insight into the effective connectivity of the seizure onset zone and the manner in which seizure activity spreads could lead to specifically-tailored therapies for epilepsy.We applied the electrical amygdala kindling model in two rhesus monkeys until these animals displayed consistent stage IV seizures. At this stage, we investigated the effective connectivity of the amygdala by means of electrical microstimulation during fMRI (EM-fMRI). In addition, we imaged changes in perfusion during a seizure using ictal SPECT perfusion imaging. The spatial overlap between the connectivity network and the ictal perfusion network was assessed both at the regional level, by calculating Dice coefficients using anatomically defined regions of interest, and at the voxel level.The kindled amygdala was extensively connected to bilateral cortical and subcortical structures, which in many cases were connected multisynaptically to the amygdala. At the regional level, the spatial extents of many of these fMRI activations and deactivations corresponded to the respective increases and decreases in perfusion imaged during a stage IV seizure. At the voxel level, however, some regions showed residual seizure-specific activity (not overlapping with the EM-fMRI activations) or fMRI-specific activation (not overlapping with the ictal SPECT activations), indicating that frequently, only a part of a region anatomically connected to the seizure onset zone participated in seizure propagation.Thus, EM-fMRI in the amygdala of electrically-kindled monkeys reveals widespread areas that are often connected multisynaptically to the seizure focus. Seizure activity appears to spread, to a large extent, via these connected areas.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 12, 2016, Pages 252–261
نویسندگان
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