کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3074829 1580955 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Abnormal white matter microstructure and increased extracellular free-water in the cingulum bundle associated with delusions in chronic schizophrenia
ترجمه فارسی عنوان
ریز ساختار ماده سفید غیر طبیعی و افزایش آب آزاد خارج سلولی در بسته بندی سینگولوم همراه با اتهامات در اسکیزوفرنی مزمن
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Free-water imaging was used to differentiate microstructural and extracellular processes.
• Patients with delusions showed increased RDT and FW in the cingulum bundle.
• Myelin abnormalities and neuroinflammation may be involved in the manifestation of delusions.

BackgroundThere is growing evidence to suggest that delusions associated with schizophrenia arise from altered structural brain connectivity. The present study investigated whether structural changes in three major fasciculi that interconnect the limbic system – the cingulum bundle, uncinate fasciculus and fornix – are associated with delusions in chronic schizophrenia patients.MethodsFree-water corrected Diffusion Tensor Imaging was used to investigate the association between delusions and both microstructural changes within these three fasciculi and extracellular changes in the surrounding free-water. Clinical data and diffusion MRI scans were obtained from 28 healthy controls and 86 schizophrenia patients, of whom 34 had present state delusions, 35 had a lifetime history but currently remitted delusions, and 17 had never experienced delusions.ResultsWhile present state and remitted delusions were found to be associated with reduced free-water corrected fractional anisotropy (FAT) and increased free-water corrected radial diffusivity (RDT) in the cingulum bundle bilaterally, extracellular free-water (FW) in the left cingulum bundle was found to be specifically associated with present state delusions in chronic schizophrenia. No changes were observed in the remaining tracts.ConclusionsThese findings suggest that state and trait delusions in chronic schizophrenia are associated with microstructural processes, such as myelin abnormalities (as indicated by decreased FAT and increased RDT) in the cingulum bundle and that state delusions are additionally associated with extracellular processes such as neuroinflammation or atrophy (as indicated by increased FW) in the left cingulum bundle.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 12, 2016, Pages 405–414
نویسندگان
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