کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3074910 1580956 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterizing “fibrofog”: Subjective appraisal, objective performance, and task-related brain activity during a working memory task
ترجمه فارسی عنوان
مشخصه "fibrofog": ارزیابی ذهنی، عملکرد عینی و فعالیت مغز مربوط به وظیفه در طول یک کار حافظه کاری
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Healthy and fibromyalgia volunteers performed the same on a working memory task.
• BOLD brain measurements during the working task were also the same between groups.
• Accuracy was related to cognitive appraisal in healthy volunteers but not in fibromyalgia.
• Cognitive appraisal correlated with different patterns of BOLD activity in each group.
• The feeling of cognitive impairment appears to be functionally separate from task performance.

The subjective experience of cognitive dysfunction (“fibrofog”) is common in fibromyalgia. This study investigated the relation between subjective appraisal of cognitive function, objective cognitive task performance, and brain activity during a cognitive task using functional magnetic resonance imaging (fMRI). Sixteen fibromyalgia patients and 13 healthy pain-free controls completed a battery of questionnaires, including the Multiple Ability Self-Report Questionnaire (MASQ), a measure of self-perceived cognitive difficulties. Participants were evaluated for working memory performance using a modified N-back working memory task while undergoing Blood Oxygen Level Dependent (BOLD) fMRI measurements. Fibromyalgia patients and controls did not differ in working memory performance. Subjective appraisal of cognitive function was associated with better performance (accuracy) on the working memory task in healthy controls but not in fibromyalgia patients. In fibromyalgia patients, increased perceived cognitive difficulty was positively correlated with the severity of their symptoms. BOLD response during the working memory task did not differ between the groups. BOLD response correlated with task accuracy in control subjects but not in fibromyalgia patients. Increased subjective cognitive impairment correlated with decreased BOLD response in both groups but in different anatomic regions. In conclusion, “fibrofog” appears to be better characterized by subjective rather than objective impairment. Neurologic correlates of this subjective experience of impairment might be separate from those involved in the performance of cognitive tasks.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 11, 2016, Pages 173–180
نویسندگان
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