کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3099250 1581574 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of Panax ginseng, zearalenol, and estradiol on sperm function
ترجمه فارسی عنوان
اثرات جینسنگ عادی، zearalenol و استرادیول بر روی عملکرد اسپرم
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب مکمل و جایگزین
چکیده انگلیسی

BackgroundEstrogen signaling pathways are modulated by exogenous factors. Panax ginseng exerts multiple activities in biological systems and is classified as an adaptogen. Zearalenol is a potent mycoestrogen that may be present in herbs and crops arising from contamination or endophytic association. The goal of this study was to investigate the impact of P. ginseng, zearalenol and estradiol in tests on spermatozoal function.MethodsThe affinity of these compounds for estrogen receptor (ER)—alpha and beta (ERα and ERβ)—was assessed in receptor binding assays. Functional tests on boar spermatozoa motility, movement and kinematic parameters were conducted using a computer-assisted sperm analyzer. Tests for capacitation, acrosome reaction (AR), and chromatin decondensation in spermatozoa were performed using microscopic analysis.ResultsZearalenol—but not estradiol (E2)- or ginseng-treated spermatozoa—decreased the percentage of overall, progressive, and rapid motile cells. Zearalenol also decreased spontaneous AR and increased chromatin decondensation. Ginseng decreased chromatin decondensation in response to calcium ionophore and decreased AR in response to progesterone (P4) and ionophore.ConclusionZearalenol has adverse effects on sperm motility and function by targeting multiple signaling cascades, including P4, E2, and calcium pathways. Ginseng protects against chromatin damage and thus may be beneficial to reproductive fitness.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ginseng Research - Volume 40, Issue 3, July 2016, Pages 251–259
نویسندگان
, , ,