Gastrointestinal Sarcoidosis and Gastric Melanosis (Video)

BackgroundSarcoidosis is a multisystem non-caseating granulomatous disease, which commonly affects the skin, joints, heart, and nervous system. Gastrointestinal sarcoidosis is rare. Likewise, only a few cases of gastric melanosis and pseudomelanosis have been reported.Patient and methodsIn this video manuscript, the authors demonstrate endoscopic and pathological findings of gastrointestinal sarcoidosis and gastric melanosis in a 53-year-old African American woman with known systemic sarcoidosis who presented with recurrent gastrointestinal bleeding.ConclusionsInternists and gastroenterologists need to be aware of potential gastrointestinal involvement in patients with sarcoidosis. Gastric melanosis is very rare and has unknown clinical significance or implications.