کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3177856 1200318 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sleep quality in a family with hereditary parkinsonism (PARK6)
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Sleep quality in a family with hereditary parkinsonism (PARK6)
چکیده انگلیسی

ObjectivesThe autosomal recessive disorder PARK6 manifests as early-onset Parkinson’s disease (PD) with a particularly mild progression. PARK6 is of particular scientific interest, since it is caused by loss-of-function mutations in the mitochondrial protein kinase PINK1 and may thus serve as a model for oxidative damage in PD and in other basal ganglia disorders. Sleep disturbances are very common in PD but have not yet been reported for PARK6 patients. The present study reports on sleep of a Spanish family with PARK6. Of the 5 siblings, 3 were homozygous and severely affected, and 2 were heterozygous and clinically asymptomatic. Research questions concerned possible differences in sleep recordings between homozygote and heterozygote siblings and similarities between PARK6 and sporadic PD sleep profiles.MethodThe data from detailed clinical interviews of the patients and their bedpartners are reported and compared with polysomnographic data from second-night recordings.ConclusionsAll siblings had good subjective and objective sleep quality. Restless legs syndrome and rapid eye movement (REM) sleep behaviour disorder (RBD) were not observed, suggesting that sleep disturbances are not commonly found in PARK6 patients. Good sleep quality and the absence of RBD might be a useful diagnostic guide in the differential diagnosis of sporadic PD versus PARK6.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sleep Medicine - Volume 9, Issue 6, August 2008, Pages 684–688
نویسندگان
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