کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3200867 | 1201945 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Advances in basic and clinical immunology in 2008
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کلمات کلیدی
ACENuclear factor-κB essential modulatorpartial DiGeorge syndromepDGSIPEXHIESHSCTCGDSCIDTLRAPCHAARTNEMOadenosine deaminase - آدنوزین دآمینازantigen-presenting cell - آنتیژن ارائه سلولHereditary angioedema - آنژیوادم ارثیAngiotensin-converting enzyme - آنژیوتانسین تبدیل آنزیمAntigen presentation - ارائه آنتیژنclinical immunology - ایمونولوژی بالینیchronic granulomatous disease - بیماری گرانولوماتوز مزمنToll-like receptor - تیالآرhighly active antiretroviral therapy - درمان ضد رتروویروسی بسیار فعالRegulatory T cells - سلولهای تی تنظیمکنندهhyper-IgE syndrome - سندرم hyper-IgEHIV infection - عفونت HIVSCID, Severe combined immunodeficiency - نقص ایمنی مرکب شدیدADA - وجود داردHematopoietic stem cell transplantation - پیوند مغز استخوانprimary immunodeficiency - کمبود ایمنی اولیه
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We reviewed selected reports in the field of basic and clinical immunology published in 2008. Research progress in the immunologic mechanisms of allergic disease included the modulation of TH2 responses by specific transcription factors and receptors associated with the innate immunity, underscoring the importance of the interactions between adaptive and innate immune mechanisms. Investigations of the pathophysiology of hereditary angioedema included a variety of host factors with roles in bradykinin metabolism and vasomotor activity, explaining the variable severity of the clinical presentation. The research focus in HIV infection has shifted from control of disease progression to the barriers for viral eradication, and the search for vaccine designs that provide immunity in the short window between infection and establishment of viral reservoirs. HIV-infected individuals who receive antiviral treatment develop a high incidence of asthma, resembling the inflammatory processes associated with immunoreconstitution. The correlation of molecular diagnosis and clinical presentation was analyzed in 4 relatively rare primary immunodeficiencies: hyper-IgE syndrome; immune dysfunction, polyendocrinopathy, enteropathy, X-linked disease; cartilage-hair hypoplasia; and nuclear factor-κB essential modulator deficiency. Studies of patients with partial DiGeorge syndrome and chronic granulomatous disease unveiled subclinical deficiencies that might have an impact in their care. Long-term outcomes from patients with severe combined immunodeficiency who received bone marrow transplants were considered successful compared with the alternative of no intervention. However, the occurrence of adverse events reinforces the need for coordinate efforts to develop optimal protocols for hematopoietic stem cell transplantation for severe immune defects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 123, Issue 2, February 2009, Pages 328-332
Journal: Journal of Allergy and Clinical Immunology - Volume 123, Issue 2, February 2009, Pages 328-332
نویسندگان
Javier MD, PhD, William T. MD, PhD,