کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
32019 44890 2016 7 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Zwitterionic polymer-protein conjugates reduce polymer-specific antibody response
ترجمه فارسی عنوان
ترکیبات پروتئین پلیمری Zwitterionic ، واکنش آنتی بادی پلیمر خاص را کاهش می دهد
کلمات کلیدی
Zwitterionic materials; Polymer-drug conjugates; Anti-drug antibodies
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی


• A zwitterionic polymer-protein conjugate does not elicit polymer-specific antibodies.
• It alleviates anti-drug antibodies.
• It improves upon the pharmacokinetics of native and polyethylene glycol conjugates.

SummaryProteins are promising therapeutics with several design challenges, such as their inherent immunogenicity due to their exogenous source or short circulation time. The common solution to such issues is the chemical conjugation of the amphiphilic polymer poly(ethylene glycol) (PEG), a process known as PEGylation. However, several studies demonstrated a decrease in protein bioactivity or an increase in the presence of specific antibodies post PEGylation, highlighting the importance of an alternative strategy. Here we compare the performance of a superhydrophilic zwitterionic polymer in protecting an immunogenic protein to PEG in (i) the maintenance of enzyme activity and stability post modification, (ii) mitigation of the antibody response elicited by the polymer and any subsequent effect on pharmacokinetics, and (iii) minimization of host response toward the underlying protein. In contrast to PEG, zwitterionic conjugation decreases host antibody response without sacrificing bioactivity or generating polymer-specific antibodies.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 11, Issue 3, June 2016, Pages 285–291
نویسندگان
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