کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
32020 44890 2016 17 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Two-dimensional non-carbonaceous materials-enabled efficient photothermal cancer therapy
ترجمه فارسی عنوان
درمان سرطان گرمانوری کارآمد مواد فعال دوبعدی غیرکربن دار
کلمات کلیدی
مواد دوبعدی؛ درمان فتوترمال؛ فناوری نانو؛ نانوسمی ؛ درمان سرطان
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی


• Overview of 2D non-carbonaceous material family, their synthetic methods and multifunctionalization for PTT.
• Summary of 2D non-carbonaceous materials for efficient PTT against cancers.
• Summary of the biological effects and biosafety of 2D non-carbonaceous materials for PTT applications.
• Discussion of the unsolved critical issues/challenges and research directions of 2D nano-carbonaceous materials for PTT.

Based on the unique two-dimensional (2D) planar nanostructure with atomic-thin thickness, abundant composition variations and the corresponding exceptional physiochemical/biological performances, the emerging inorganic 2D nanomaterials with high biocompatibility have been becoming one of the most promising material nanosystems of great potentials for applications in biomedicine. This review focuses on the unique photothermal-conversion property of several new representative 2D nanomaterials beyond graphene for photothermal conversion-based tumor hyperthermia and theranostic biomedicine, including transition metal dichalcogenides (TMDCs, such as MoS2, WS2, TiS2 and Bi2Se3), black phosphorous (P), metal Pd nanosheets and their composite nanosheets. Based on high photothermal-conversion efficiency of these 2D nanomaterials, this review first highlights the design, synthesis and surface functionalization of 2D nanomaterials for photothermal therapy (PTT) ablation of cancer cells/tissues. The representative strategies of functionalizing these 2D nanomaterials for imaging-guided PTT and PTT-based synergistic cancer therapy are then discussed. The preliminary progresses on biosafety evaluation of these 2D nanomaterials were also briefly summarized and discussed. Finally, we discussed the state-of-art unsolved critical issues and challenges, and outlooked further research directions of 2D nanomaterials for potential clinical translation for PTT tumor ablation. It is believed that the fast development and promising performance of these biocompatible 2D materials can provide a highly efficient nanoplatform for combating cancer by hyperthermia.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (402 K)Download as PowerPoint slideBased on the unique two-dimensional (2D) planar nanostructure with atomic-thin thickness, abundant composition variations and the corresponding exceptional physiochemical/biological performances, the emerging inorganic 2D nanomaterials with high biocompatibility have been becoming one of the most promising material nanosystems of great potentials for applications in biomedicine. This review focuses on the unique photothermal-conversion property of several new representative 2D nanomaterials beyond graphene for photothermal conversion-based tumor hyperthermia and theranostic biomedicine, including transition metal dichalcogenides (TMDCs, such as MoS2, WS2, TiS2 and Bi2Se3), black phosphorous (P), metal Pd nanosheets and their composite nanosheets. Based on high photothermal-conversion efficiency of these 2D nanomaterials, this review first highlights the design, synthesis and surface functionalization of 2D nanomaterials for photothermal therapy (PTT) ablation of cancer cells/tissues. The representative strategies of functionalizing these 2D nanomaterials for imaging-guided PTT and PTT-based synergistic cancer therapy are then discussed. The preliminary progresses on biosafety evaluation of these 2D nanomaterials were also briefly summarized and discussed. Finally, we discussed the state-of-art unsolved critical issues and challenges, and outlooked further research directions of 2D nanomaterials for potential clinical translation for PTT tumor ablation. It is believed that the fast development and promising performance of these biocompatible 2D materials can provide a highly efficient nanoplatform for combating cancer by hyperthermia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 11, Issue 3, June 2016, Pages 292–308
نویسندگان
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