کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
323036 540468 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interaction of bisphenol A (BPA) and soy phytoestrogens on sexually dimorphic sociosexual behaviors in male and female rats
ترجمه فارسی عنوان
تعامل بیسفنولA و استروژن های گیاهی بر رفتارهای جنسی اجتماعی دوشکلی جنسی در رت های نر و ماده
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


• Environmental chemicals and hormonally active diets can affect brain development and behavior.
• Here we tested the individual and interactive effects BPA, soy diet and genistein on juvenile sociality and open field behavior.
• Soy diet but not BPA had sex specific effects.
• Impacted behaviors included suppressed novelty preference, and open field exploration in females.
• These data reinforce the importance of considering environmental factors when examining brain and behavior.

Concerns have been raised regarding the potential for endocrine disrupting compounds (EDCs) to alter brain development and behavior. Developmental exposure to bisphenol A (BPA), a ubiquitous EDC, has been linked to altered sociosexual and mood-related behaviors in various animal models and children but effects are inconsistent across laboratories and animal models creating confusion about potential risk in humans. Exposure to endocrine active diets, such as soy, which is rich in phytoestrogens, may contribute to this variability. Here, we tested the individual and combined effects of low dose oral BPA and soy diet or the individual isoflavone genistein (GEN; administered as the aglycone genistin (GIN)) on rat sociosexual behaviors with the hypothesis that soy would obfuscate any BPA-related effects. Social and activity levels were unchanged by developmental exposure to BPA but soy diet had sex specific effects including suppressed novelty preference, and open field exploration in females. The data presented here reinforce that environmental factors, including anthropogenic chemical exposure and hormone active diets, can shape complex behaviors and even reverse expected sex differences.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hormones and Behavior - Volume 84, August 2016, Pages 121–126
نویسندگان
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