کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
324453 1432928 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gestational Exposure to Selective Serotonin Reuptake Inhibitors and Offspring Psychiatric Disorders: A National Register-Based Study
ترجمه فارسی عنوان
مواجهه با حاملگی برای بازدارنده های انتخابی بازجذب سروتونین و اختلالات روانپزشکی فرزندان: مطالعه ثبت ملی مبتنی بر
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
چکیده انگلیسی

ObjectiveTo investigate the impact of gestational exposure to selective serotonin reuptake inhibitors (SSRIs) on offspring neurodevelopment.MethodThis is a cohort study using national register data in Finland between the years 1996 and 2010. Pregnant women and their offspring were categorized into 4 groups: SSRI exposed (n = 15,729); exposed to psychiatric disorder, no antidepressants (n = 9,651); exposed to SSRIs only before pregnancy (n = 7,980); and unexposed to antidepressants and psychiatric disorders (n = 31,394). We investigated the cumulative incidence of offspring diagnoses of depression, anxiety, autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD) for the 4 groups from birth to 14 years, adjusting for confounders.ResultsThe cumulative incidence of depression among offspring exposed prenatally to SSRIs was 8.2% (95% CI = 3.1–13.3%) by age 14.9 years, compared with 1.9% (95% CI = 0.9–2.9%) in the psychiatric disorder, no medication group (adjusted hazard ratio [HR] = 1.78; 95% CI = 1.12–2.82; p = .02) and to 2.8% (95% CI = 1.4–4.3%) in the SSRI discontinued group (HR = 1.84; 95% CI = 1.14–2.97; p = .01). Rates of anxiety, ASD, and ADHD diagnoses were comparable to rates in offspring of mothers with a psychiatric disorder but no medication during pregnancy. Comparing SSRI exposed to unexposed individuals, the HRs were significantly elevated for each outcome.ConclusionPrenatal SSRI exposure was associated with increased rates of depression diagnoses in early adolescence but not with ASD or ADHD. Until confirmed, these findings must be balanced against the substantial adverse consequences of untreated maternal depression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Child & Adolescent Psychiatry - Volume 55, Issue 5, May 2016, Pages 359–366
نویسندگان
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