Orthopedic application of spikenard herbal rhizome decorated microstructured polymer biocomposites and their in vitro cytotoxicity

• Polymer biocomposite was successfully synthesized by free radical polymerization technique.
• Biocomposites enhance better antibacterial and antifungal activities against various microorganisms.
• Evaluated the orthopedic infection bacteria by serial dilution method.
• Morphological structure of biocomposite characterized by AFM.
• Exhibit the less in vitro cytotoxicity against HaCaT cells.

The present study explores the synthesis of highly potential polymer biocomposite from Nardostachys jatamansi rhizome extract. The polymer biocomposites were synthesized from methyl methacrylate by free radical polymerization. ATR-IR enunciate the functional groups attributed at 956 cm−1 (aromatic), a peak appeared at 1685 cm−1 (CO), 1186 cm−1 (OCH3), 1149 cm−1 (COC) framework and 1279 cm−1 (CO), which are good agreement for the formation composites. The quantitative evaluations of antimicrobial studies were analyzed by serial dilution method and also improved activity in orthopedic infection pathogens. Cytocompatibility was analyzed by keratinocyte cell lines and it may be used for various biomedical applications.

Figure optionsDownload as PowerPoint slide