کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3259100 1207568 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fasting hyperinsulinaemia and 2-h glycaemia predict coronary heart disease in patients with type 2 diabetes
ترجمه فارسی عنوان
هیپرانسولینمی ناشتا و گلیسمی 2 ساعته بیماری قلبی عروقی را در بیماران مبتلا به دیابت نوع 2 پیش بینی می کند
کلمات کلیدی
بیماری قلبی عروقی؛ Hyperinsulinaemia؛ مقاومت به انسولین؛ قند خون 2 ساعته؛ دیابت نوع 2، انجمن دیابت آمریکا؛ CVD، بیماری قلبی عروقی؛ DBP، فشار خون دیاستولیک؛ EMRC، مرکز تحقیقات غدد درون ریز و متابولیسم
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

AimPatients with diabetes are at greater risk of cardiovascular events. Insulin resistance (IR) and hyperinsulinaemia are both related to an increased cardiovascular risk, but whether IR predicts coronary heart disease (CHD) independently of other risk factors in patients with type 2 diabetes (T2D) is a topic of considerable controversy. The aim of the present study was to evaluate the prospective relationship of fasting insulin, HOMA-IR, fasting plasma glucose (FPG) and 2-h post-load glucose (2hPG) load with CHD incidence among such patients.MethodsA total of 2607 patients with T2D were enrolled in a community-dwelling cohort and followed for an average of 7.2 years. Conventional CHD risk factors, FPG, 2hPG, fasting insulin levels and HOMA-IR index were measured at baseline. Cox regression hazard ratios (HRs) were used to assess CHD risk.ResultsA total of 299 ‘hard’ CHD events were registered (in 114 women and 185 men). Increasing levels of fasting insulinaemia were positively associated with CHD incidence. This correlation persisted after controlling for gender, body mass index, blood pressure, lipid profile, medication use and HbA1c [HR for each increase in quartile (fully adjusted model): 1.18 (95% CI: 1.06–1.32); P < 0.01]. 2hPG showed a non-linear association with incident CHD [HR of highest vs lowest quartile: 1.64 (95% CI: 1.03–2.61)]. Fasting glycaemia was not associated with CHD risk, whereas HOMA-IR had a direct and independent correlation with CHD risk [HR for each one-quartile increase: 1.19 (95% CI: 1.07–1.34); P < 0.01].ConclusionFasting insulin levels are positively associated with incidence of CHD in T2D. Furthermore, 2hPG appears to be a significant predictor of incident CHD independently of other risk factors, including HbA1c. These findings suggest that strategies targeting the reduction of insulinaemia and post-load glycaemia may be useful for preventing cardiovascular complications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes & Metabolism - Volume 42, Issue 1, February 2016, Pages 55–61
نویسندگان
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