کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3261182 1207681 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Seronegative celiac disease: Shedding light on an obscure clinical entity
ترجمه فارسی عنوان
بیماری سلیاک سرم منفی: تاباندن نور بر یک نهاد بالینی مبهم
کلمات کلیدی
اتوآنتی بادی؛ اختلالات خود ایمنی. آنتروپاتی خودایمن؛ نقص ایمنی متغیر شایع؛ المزارتان؛ بیماری سلیاک سرم منفی؛ آتروفی پرزهای روده
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

BackgroundAlthough serological tests are useful for identifying celiac disease, it is well established that a minority of celiacs are seronegative.AimTo define the prevalence and features of seronegative compared to seropositive celiac disease, and to establish whether celiac disease is a common cause of seronegative villous atrophy.MethodsStarting from 810 celiac disease diagnoses, seronegative patients were retrospectively characterized for clinical, histological and laboratory findings.ResultsOf the 810 patients, fourteen fulfilled the diagnostic criteria for seronegative celiac disease based on antibody negativity, villous atrophy, HLA-DQ2/-DQ8 positivity and clinical/histological improvement after gluten free diet. Compared to seropositive, seronegative celiac disease showed a significantly higher median age at diagnosis and a higher prevalence of classical phenotype (i.e., malabsorption), autoimmune disorders and severe villous atrophy. The most frequent diagnosis in the 31 cases with seronegative flat mucosa was celiac disease (45%), whereas other diagnoses were Giardiasis (20%), common variable immunodeficiency (16%) and autoimmune enteropathy (10%).ConclusionsAlthough rare seronegative celiac disease can be regarded as the most frequent cause of seronegative villous atrophy being characterized by a high median age at diagnosis; a close association with malabsorption and flat mucosa; and a high prevalence of autoimmune disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 48, Issue 9, September 2016, Pages 1018–1022
نویسندگان
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