کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3261222 1207682 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High-grade anal intraepithelial neoplasia: Progression to invasive cancer is not a certainty
ترجمه فارسی عنوان
نئوپلازی داخل مقعدی با درجه بالا: پیشرفت به سرطان تهاجمی قطعی نیست
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

BackgroundThe incidences of high-grade anal intraepithelial neoplasia (HSIL) and superficially invasive squamous cell carcinomas (SISCCA) related to human papillomavirus (HPV) have increased. These lesions can progress to invasive anal cancer. The aim of the study was to assess the clinical outcome with a special focus on the healing rate.MethodsForty-six consecutive patients (M/F: 35/11; HIV+: 30) with histologically proven HSIL lesions (N = 41) or SISCCA (N = 5) were enrolled in a follow-up survey.ResultsOf the 46 patients, 40 were treated by excision (n = 9), electrocoagulation (n = 13), topical treatment (n = 2) or combined strategies (n = 16). After a mean follow-up of 35 (27–43) months, only one patient progressed to an invasive cancer. Regression and healing were observed in 14 (30%) and 15 (33%) patients. The cumulative probabilities of healing were 14%, 49% and 74% after 1, 3 and 5 years. None of the current smokers healed. Heterosexual patients, sexual abstinence, patients older than 44 years old, non-smokers, patients without any past history of condyloma and those with less than 2 high-risk HPVs at baseline were more likely to heal.ConclusionProgression to invasive cancer is a rare event. Large, prospective cohort studies are needed to plan coherent strategies for both follow-up and treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 48, Issue 7, July 2016, Pages 806–811
نویسندگان
, , , , , , , , ,