کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
327540 542925 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Riluzole combination therapy for moderate-to-severe major depressive disorder: A randomized, double-blind, placebo-controlled trial
ترجمه فارسی عنوان
درمان ترکیبی ریلوزول برای اختلال افسردگی متوسط تا شدید: یک آزمایش کنترل شده دو سو کور با پلاسبو تصادفی
کلمات کلیدی
کارازمایی بالینی؛ گلوتامات؛ اختلال افسردگی اساسی. ریلوزول
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Recent evidences suggest that glutamatergic dysregulation may contribute to the pathophysiology of major depressive disorder.
• In this study, significantly greater response with greater speed to treatment was observed in the riluzole group than the placebo group.
• A 6-week course of treatment with riluzole as adjunct to citalopram showed a favorable efficacy profile in patients with MDD.

Recent evidences suggest that glutamatergic dysregulation implicated in neural plasticity and cellular resilience may contribute to the pathophysiology of Major Depressive Disorder (MDD). Riluzole, which exerts its effect by targeting glutamate neurotransmission, has shown antidepressant effect in recent preclinical, observational and open label studies. This study aimed to assess the efficacy and tolerability of riluzole in patients with MDD. Sixty-four inpatients with diagnosis of moderate to severe major depressive disorder participated in a parallel, randomized, controlled trial, and sixty patients underwent 6 weeks treatment with either riluzole (50 mg/bid) plus citalopram (40 mg/day) or placebo plus citalopram (40 mg/day). All participants were inpatients for the whole duration of the study. Patients were assessed using Hamilton depression rating scale (HDRS) at baseline and weeks 2, 4 and 6. The primary outcome measure was to assess the efficacy of riluzole compared to placebo in improving the depressive symptoms. General linear model repeated measures demonstrated significant effect for time × treatment interaction on HDRS [F (1.86, 107.82) = 8.63, p < 0.001]. Significantly greater improvement was observed in HDRS scores in the riluzole group compared to the placebo group from baseline HDRS score at weeks 2, 4 and 6 (p < 0.001, p = 0.001, p = 0.002, respectively). Significantly greater response with greater speed to treatment was observed in the riluzole group than the placebo group. No serious adverse event occurred. This study showed a favorable safety and efficacy profile in patients with major depressive disorder. Larger controlled studies with longer treatment periods are needed to investigate long term safety, efficacy and optimal dosing.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 75, April 2016, Pages 24–30
نویسندگان
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