کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3350203 1591377 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HLA class II genotypes are not associated with age related macular degeneration in a case-control, population-based study
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
HLA class II genotypes are not associated with age related macular degeneration in a case-control, population-based study
چکیده انگلیسی

Multiple lines of evidence support an immunologic basis and genetic disposition for the development of age-related macular degeneration (AMD). Comprehensive human leukocyte antigens (HLA) class II typing at four loci (DRB1, DQA1, DQB1, and DPB1) was assessed using next generation sequencing methods and tested for association with age-related macular degeneration (AMD) in a case-control study of 456 AMD cases and 499 controls from the population-based Study of Osteoporotic Fractures (SOF) cohort. No statistically significant associations were identified for any of the class II loci and a previously identified association between DRB1*13:01 was not replicated in this dataset. These results reported here suggest that common HLA class II genetic variation does not contribute to AMD disease risk.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 76, Issues 2–3, March 2015, Pages 142–145
نویسندگان
, , , , , , , ,