کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3368722 1592351 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Purpura fulminans associated with acute West Nile virus encephalitis
ترجمه فارسی عنوان
Purpura fulminans مرتبط با آنسفالیت ویروس حاد نیل غربی
کلمات کلیدی
پورپورا؛ فلوامین ها؛ غرب؛ نیل؛ ویروس؛ انسفالیت
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی

Purpura fulminans is a progressive thrombotic disorder that presents with widespread purpura due to deficiency or dysfunction of protein C or protein S. Lesions present as well-demarcated erythematous macules that progress to irregular areas of hemorrhagic necrosis.West Nile virus is a member of the Flaviviridae family transmitted to humans through the bite of various mosquito species. It manifests as West Nile fever in 25% of those infected and less commonly as neuroinvasive disease. An African American man in his fortiespresented with altered mental status and was noted to have evidence of disseminated intravascular coagulation according to his lab data. He then developed dusky skin discoloration and systemic flaccid bullae with desquamation. Biopsy was consistent with purpura fulminans and the patient eventually developed symmetric peripheral gangrene, requiring amputations of all four extremities. Infectious work up revealed positive testing for IgM and IgG antibodies in serum and cerebrospinal fluid leading to the diagnosis of acute West Nile Virus encephalitis. We present this case to describe the rarely reported association of purpura fulminans with West Nile Virus infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Virology - Volume 75, February 2016, Pages 1–4
نویسندگان
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