کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
338899 1363525 2016 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Implications for reactive oxygen species in schizophrenia pathogenesis
ترجمه فارسی عنوان
پیامدها برای گونه های اکسیژن فعال در پاتوژنز اسکیزوفرنی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی

Oxidative stress is a well-recognized participant in the pathophysiology of multiple brain disorders, particularly neurodegenerative conditions such as Alzheimer's and Parkinson's diseases. While not a dementia, a wide body of evidence has also been accumulating for aberrant reactive oxygen species and inflammation in schizophrenia. Here we highlight roles for oxidative stress as a common mechanism by which varied genetic and epidemiologic risk factors impact upon neurodevelopmental processes that underlie the schizophrenia syndrome. While there is longstanding evidence that schizophrenia may not have a single causative lesion, a common pathway involving oxidative stress opens the possibility for intervention at susceptible phases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 176, Issue 1, September 2016, Pages 52–71
نویسندگان
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