کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3393705 1592764 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Risk factors for Plasmodium falciparum and Plasmodium vivax gametocyte carriage in Papua New Guinean children with uncomplicated malaria
ترجمه فارسی عنوان
عوامل خطر ابتلا به گاستوسیت پلاسمودیوم فالسیپاروم و پلاسمودیوم ویواکس در کودکان پاپوآ گینه نو مبتلا به مالاریا بدون عارضه
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
چکیده انگلیسی


• Gametocytaemia risk factors were assessed pre- and post-treatment in young children.
• Pre-treatment P. falciparum gametocytaemia reflected prior infections/immunity.
• Post-treatment P. falciparum gametocytaemia was more common with anaemia.
• Pre-and post-treatment P. vivax gametocytaemia paralleled the asexual parasitaemia.
• These differences reflect bone marrow maturation vs rapid development in the blood.

There are limited data on gametocytaemia risk factors before/after treatment with artemisinin combination therapy in children from areas with transmission of multiple Plasmodium species. We utilised data from a randomised trial comparing artemether-lumefantrine (AL) and artemisinin-naphthoquine (AN) in 230 Papua New Guinean children aged 0.5–5 years with uncomplicated malaria in whom determinants of gametocytaemia by light microscopy were assessed at baseline using logistic regression and during follow-up using multilevel mixed effects modelling. Seventy-four (32%) and 18 (8%) children presented with P. falciparum and P. vivax gametocytaemia, respectively. Baseline P. falciparum gametocytaemia was associated with Hackett spleen grade 1 (odds ratio (95% CI) 4.01 (1.60–10.05) vs grade 0; P < 0.001) and haemoglobin (0.95 (0.92–0.97) per 1 g/L increase; P < 0.001), and P. falciparum asexual parasitaemia in slide-positive cases (0.36 (0.19–0.68) for a 10-fold increase; P = 0.002). Baseline P. vivax gametocytaemia was associated with Hackett grade 2 (12.66 (1.31–122.56); P = 0.028), mixed P. falciparum/vivax infection (0.16 (0.03–1.00); P = 0.050), P. vivax asexual parasitaemia (5.68 (0.98–33.04); P = 0.053) and haemoglobin (0.94 (0.88–1.00); P = 0.056). For post-treatment P. falciparum gametocytaemia, independent predictors were AN vs AL treatment (4.09 (1.43–11.65)), haemoglobin (0.95 (0.93–0.97)), presence/absence of P. falciparum asexual forms (3.40 (1.66–0.68)) and day post-treatment (0.086 (0.82–0.90)) (P < 0.001). Post-treatment P. vivax gametocytaemia was predicted by presence of P. vivax asexual forms (596 (12–28,433); P < 0.001). Consistent with slow P. falciparum gametocyte maturation, low haemoglobin, low asexual parasite density and higher spleen grading, markers of increased prior infection exposure/immunity, were strong associates of pre-treatment gametocyte positivity. The persistent inverse association between P. falciparum gametocytaemia and haemoglobin during follow-up suggests an important role for bone marrow modulation of gametocytogenesis. In P. vivax infections, baseline and post-treatment gametocyte carriage was positively related to the acute parasite burden, reflecting the close association between the development of asexual and sexual forms.

Risk factors for Plasmodium falciparum or Plasmodium vivax gametocyte carriage other than (as shown) treatment are explored in this study involving young Papua New Guinean children.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Tropica - Volume 160, August 2016, Pages 1–8
نویسندگان
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