کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3394940 | 1592829 | 2015 | 4 صفحه PDF | دانلود رایگان |
• rpoB gene mutations in clinical strains of Propionibacterium acnes lead to rifampicin resistance.
• Mutations were found in both clusters I and II.
• High-level rifampicin resistance occurred in clinical strains of P. acnes.
• Mutation at position 442 constitutes a hot spot.
• Susceptibility testing is clearly important in deep or biofilm-related infections.
We described for the first time the amino acid substitutions conferring rifampicin resistance in eight Propionibacterium acnes strains isolated from patients with biofilm or device-related infections. We identified different mutations in cluster I and one mutation, never reported, in cluster II of the rpoB gene (I480V) associated with the most frequent one in cluster I (S442L). Half of the patients previously received treatment with rifampicin.
Journal: Anaerobe - Volume 34, August 2015, Pages 116–119