کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3405637 1223472 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Resistance to antimalarial drugs: An endless world war against Plasmodium that we risk losing
ترجمه فارسی عنوان
مقاومت به داروهای ضد مالاریا: یک جنگ جهانی بی پایان در برابر پلاسمودیوم که خطر ابتلا به آن را دارد
کلمات کلیدی
مالاریا، پلاسمودیوم فالسیپاروم، پلاسمودیوم ویواکس، مقاومت در برابر مواد مخدر، مقاومت آرتمیسینین، نشانگرهای مولکولی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی


• This review describes the ‘state of the art’ of Plasmodium falciparum resistance to the main antimalarial drugs.
• Particular emphasis has been placed on the emergence of artemisinin resistance in Southeast Asia.
• A brief note on what happens in Plasmodium vivax is also discussed.

The objective of this review was to describe the ‘state of the art’ of Plasmodium falciparum resistance to the main antimalarial drugs. A brief note on Plasmodium vivax is also included. Resistance of P. falciparum to the various antimalarials has a long history of hits and misses. During the last 60 years, the pace at which this parasite has developed resistance to antimalarial drugs has exceeded the pace at which new drugs have been developed. In the last decade, the introduction of artemisinin-based combination therapies (ACTs) as a first-line drug treatment for non-complicated P. falciparum malaria had led to extraordinary results in disease control, especially in sub-Saharan Africa. However, the emergence and spread of resistance to artemisinin in Southeast Asia jeopardise these results. In conclusion, the possible spread of artemisinin resistance in Africa should be considered as an epochal disaster.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Global Antimicrobial Resistance - Volume 3, Issue 2, June 2015, Pages 58–63
نویسندگان
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