کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3930219 1410017 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bisphenol A and ovarian steroidogenesis
ترجمه فارسی عنوان
بیس فنول A و استروئیدوژنز تخمدان
کلمات کلیدی
آروماتاز؛ بیسفنول A ؛ استروژن؛ هورمون های استروئیدی جنسی؛ گاما گیرنده فعال شدن پراکسی زوم تکثیر (PPAR-γ)
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

Bisphenol A is widely used as a component in polycarbonate plastics for food and beverage packaging, epoxy linings for canned foods, and dental sealants, among other applications. Experimental literature demonstrates BPA's affinity for estrogen receptors and downstream effects on estrogen-responsive genes. Additional data suggest that BPA reduces endogenous estrogen synthesis, likely by antagonizing ovarian enzyme activities involved in sex-steroid hormone synthesis. More specifically, evidence indicates BPA-mediated disruption of STAR, CYP450scc, and HSD-3β in theca cells and CYP450 aromatase activity in granulosa cells. Yet the results of the few human studies reported to date are equivocal. It also remains in question the extent to which BPA penetrates developing ovarian follicles. Uncertainty as to the relevance of experimental BPA doses and administration routes for common human exposure levels limits extrapolation of experimental results. To more definitively address the potential risk of BPA on human ovarian steroidogenesis, additional experimental studies using biologically active BPA doses likely to reflect those within the ovarian follicle will be necessary, as will additional prospective investigations in human populations with the use of standardized assay methodology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 106, Issue 4, 15 September 2016, Pages 857–863
نویسندگان
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