کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4130968 | 1271166 | 2016 | 4 صفحه PDF | دانلود رایگان |
Leiomyosarcoma is the most common sarcoma of the uterine corpus, however, uterine dedifferentiated leiomyosarcoma remains a poorly characterized entity. Dedifferentiation in leiomyosarcoma can be defined as the occurrence of a high-grade undifferentiated sarcoma in association with a lower-grade sarcoma that demonstrates morphologic and immunophenotypic evidence of myogenic differentiation. The occurrence of extensive heterologous elements in the high-grade area can be problematic confusing the tumor with other more specific types of high-grade sarcomas. Available reports of this entity indicate aggressive biological behavior and poor prognosis. Herein, we describe a case of a 35-year-old woman who presented with menorrhagia and underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. The histopathological examination of the surgical specimen revealed features of a low-grade leiomyosarcoma juxtaposed to a high-grade sarcoma with osteosarcomatous differentiation.
Journal: Diagnostic Histopathology - Volume 22, Issue 5, May 2016, Pages 206–209