کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4312017 1612917 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Altered neural connectivity in adult female rats exposed to early life social stress
ترجمه فارسی عنوان
اتصال عصبی تغییریافته در رت ماده بالغ در معرض استرس اجتماعی در اوایل زندگی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


• Early life social stress induces changes in resting state functional connectivity.
• The prefrontal cortex and hippocampus exhibited particularly robust changes.
• Stress affects connectivity in social and depression relevant brain regions.

The use of a variety of neuroanatomical techniques has led to a greater understanding of the adverse effects of stress on psychiatric health. One recent advance that has been particularly valuable is the development of resting state functional connectivity (RSFC) in clinical studies. The current study investigates changes in RSFC in F1 adult female rats exposed to the early life chronic social stress (ECSS) of the daily introduction of a novel male intruder to the cage of their F0 mothers while the F1 pups are in the cage. This ECSS for the F1 animals consists of depressed maternal care from their F0 mothers and exposure to conflict between their F0 mothers and intruder males. Analyses of the functional connectivity data in ECSS exposed adult females versus control females reveal broad changes in the limbic and reward systems, the salience and introspective socioaffective networks, and several additional stress and social behavior associated nuclei. Substantial changes in connectivity were found in the prefrontal cortex, nucleus accumbens, hippocampus, and somatosensory cortex. The current rodent RSFC data support the hypothesis that the exposure to early life social stress has long term effects on neural connectivity in numerous social behavior, stress, and depression relevant brain nuclei. Future conscious rodent RSFC studies can build on the wealth of data generated from previous neuroanatomical studies of early life stress and enhance translational connectivity between animal and human fMRI studies in the development of novel preventative measures and treatments.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research SreeTestContent1 - Volume 316, 1 January 2017, Pages 225–233
نویسندگان
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