Behavioral effects of chronically elevated corticosterone in subregions of the medial prefrontal cortex

• Corticosterone implants in prelimbic or infralimbic cortices reduce open arm exploration.
• Elevated corticosterone in the anterior cingulate cortex didn’t affect plus-maze behavior.
• All behavioral effects of corticosterone were specific to open arm exploration.
• Corticosterone’s effects in the medial prefrontal cortex are anatomically specific.

The medial prefrontal cortex is a key mediator of behavioral aspects of the defense response. Since chronic exposure to elevated glucocorticoids alters the dendritic structure of neurons in the medial prefrontal cortex, such exposure may alter behavioral responses to danger as well. We examined the effects of chronically elevated corticosterone in discrete regions of the medial prefrontal cortex on exploration of the elevated plus-maze. Chronically elevated corticosterone in the prelimbic or infralimbic cortices reduced open arm exploration. This effect was specific to the ventral regions of the medial prefrontal cortex as corticosterone had no effect on plus-maze exploration when administered into the anterior cingulate cortex. Taken together, these findings demonstrate clear regional differences for the effects of corticosterone in the medial prefrontal cortex.