کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4323563 1613800 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Memantine improves memory impairment and depressive-like behavior induced by amphetamine withdrawal in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Memantine improves memory impairment and depressive-like behavior induced by amphetamine withdrawal in rats
چکیده انگلیسی


• Withdrawal of AMPH induces depressive-like behavior and deficits in cognition.
• Memantine attenuates the aforementioned effects of AMPH.
• Memantine effect on memory is connected with the muscarinic cholinergic receptors.
• Memantine exerts antidepressant-like effects via the glutamatergic system.

Amphetamine (AMPH) induces deficits in cognition, and depressive-like behavior following withdrawal. The aim of the present study was to investigate whether pre-treatment with memantine (5 mg/kg, i.p.), a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, attenuates memory impairment induced by withdrawal from a 1 day binge regimen of AMPH (2 mg/kg, four times every 2 h, i.p.), in the novel object recognition test in rats. Herein, the influence of scopolamine (0.1 mg/kg), an antagonist of the muscarinic cholinergic receptors, and the impact of MK-801 (0.1 mg/kg), an antagonist of the NMDA receptors, on the memantine effect, were ascertained. Furthermore, the impact of memantine (5; 10; 20 mg/kg, i.p.) was measured on depression-like effects of abstinence, 14 days after the last AMPH treatment (2 mg/kg×1×14 days), in the forced swim test. In this test, the efficacy of memantine was compared to that of tricyclic antidepressant imipramine (10; 20; 30 mg/kg, i.p.). Our study indicated that withdrawal from a binge regimen of AMPH impaired recognition memory. This effect was attenuated by administration of memantine at both 72 h and 7 days of withdrawal. Moreover, prior administration of scopolamine, but not MK-801, decreased the memantine-induced recognition memory improvement. In addition, memantine reversed the AMPH-induced depressive-like behavior in the forced swim test in rats. The antidepressant-like effects of memantine were stronger than those of imipramine. Our study indicates that memantine constitutes a useful approach towards preventing cognitive deficits induced by withdrawal from an AMPH binge regimen and by depressive-like behavior during AMPH abstinence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1642, 1 July 2016, Pages 389–396
نویسندگان
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