کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4354117 | 1299015 | 2015 | 9 صفحه PDF | دانلود رایگان |
• Reconsolidation exists broadly throughout the nervous system.
• Reactivation of memory traces induces synaptic depotentiation and repotentiation.
• We propose that depotentiation and repotentiation preserve synaptic strength.
• Reconsolidation may reflect a general regulatory mechanism of synaptic plasticity.
Memory reconsolidation is a protein synthesis-dependent process that preserves, in some form, memories that have been destabilized through recall. Reconsolidation is a nearly universal phenomenon, occurring in a diverse array of species and learning tasks. The function of reconsolidation remains unclear but it has been proposed as a mechanism for updating or strengthening memories. Observations of an analog of reconsolidation in vitro and in sensory systems indicate that reconsolidation is unlikely to be a learning-specific phenomenon and may serve a broader function. We propose that reconsolidation arises from the activity-dependent induction of two coincident but opposing processes: the depotentiation and repotentiation of strengthened synapses. These processes suggest that reconsolidation reflects a fundamental mechanism that regulates and preserves synaptic strength.
Journal: - Volume 38, Issue 6, June 2015, Pages 336–344