کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4356657 | 1615781 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
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چکیده انگلیسی
β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms −52G>A (rs1799946), −44C>G (rs1800972) and −20G>A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the disease. However we cannot exclude that this lack of association could be due to the low number of subjects analyzed, as suggested by the low statistical power achieved for the three analyzed SNPs (values between 0.16 and 0.50).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brazilian Journal of Microbiology - Volume 47, Issue 2, April–June 2016, Pages 389–393
Journal: Brazilian Journal of Microbiology - Volume 47, Issue 2, April–June 2016, Pages 389–393
نویسندگان
Ronaldo Celerino da Silva, Heidi Lacerda Alves da Cruz, Lucas André Cavalcanti Brandão, Rafael Lima Guimarães, Lilian Maria Lapa Montenegro, Haiana Charifker Schindler, Ludovica Segat, Sergio Crovella,