کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4407605 1618814 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hormetic effect and mechanism of imidazolium-based ionic liquids on the nematode Caenorhabditis elegans
ترجمه فارسی عنوان
اثر مهار کننده و مکانیسم مبتنی بر ایمیدازولیوم مایعات یونی بر نماتد به نام کینورهابدیتیس الگانس
کلمات کلیدی
مایعات یونی؛ C. elegans؛ هورمونیزه طول عمر؛ ROS؛ RT-PCR
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی


• Ionic liquids showed hormetic effects on the lifespan of Caenorhabditis elegans.
• Ionic liquids prolonged the lifespan of C. elegans by removing the ROS.
• sod-5 and daf-16 genes play an important role in the lifespan extension.
• The hormetic effect caused by ionic liquids might be an overcompensation response.

In the present study, we used Caenorhabditis elegans assay system to investigate in hormetic effects of imidazolium-based bromide Ionic Liquids (ILs) and explored the possible underlying mechanism. Firstly, C. elegans was treated with ILs with different alkyl chain lengths at different concentrations. We found that exposure to ILs at 0.01 mg/L extended the mean lifespan of C. elegans and the ILs with longer alkyl chain showed more obvious effects. To investigate the possible mechanism, the nematodes were exposed to the three ILs at 0.01 mg/L for 2, 5, 7, 9 and 11 days. The levels of reactive oxygen species (ROS) in C. elegans increased significantly when treated for 2 days and then declined gradually compared to those of respective controls as time went on. After exposure for 11 days, the ROS levels and liposuscin accumulation were significantly lower in the treated groups than those of control group. Meanwhile, the expression of aging-related genes sod-5 and daf-16 were both massively up-regulated for the three ILs examined. Our results show that low concentration of ILs exert hormetic effect on C. elegans. ROS generation and expression of aging-related genes may play important roles in the IL-induced hormetic effect on C. elegans.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 157, August 2016, Pages 65–70
نویسندگان
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