کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4419340 | 1618935 | 2016 | 6 صفحه PDF | دانلود رایگان |
• Development of LC–MS/MS acetaminophen quantification method in aquatic organisms.
• Method is robust, sensitive and reproducible with a LOQ of 5 pg on column.
• Method application by evaluating acetaminophen uptake in Mucor hiemalis.
• Acetaminophen was taken up and bioaccumulated with time relative to biomass.
Acetaminophen is a pharmaceutical, frequently found in surface water as a contaminant. Bioremediation, in particular, mycoremediation of acetaminophen is a method to remove this compound from waters. Owing to the lack of quantitative analytical method for acetaminophen in aquatic organisms, the present study aimed to develop a method for the determination of acetaminophen using LC–MS/MS in the aquatic fungus Mucor hiemalis. The method was then applied to evaluate the uptake of acetaminophen by M. hiemalis, cultured in pellet morphology. The method was robust, sensitive and reproducible with a lower limit of quantification of 5 pg acetaminophen on column. It was found that M. hiemalis internalize the pharmaceutical, and bioaccumulate it with time. Therefore, M. hiemalis was deemed a suitable candidate for further studies to elucidate its pharmaceutical tolerance and the longevity in mycoremediation applications.
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Journal: Ecotoxicology and Environmental Safety - Volume 128, June 2016, Pages 230–235