Transcellular route as the most probable explanation for the presence of plasminogen in mammal׳s milk

• The presence of proteins in milk as a consequence of paracellular leakage is a dubious explanation.
• The evidences for the case of milk plasminogen are considered.
• It is concluded that transcellular passage is the most probable explanation for the presence of plasminogen in milk.

Paracellular and transcellular route of passage of several milk metabolites, albumin, lactic acid dehydrogenase and plasminogen from the systemic circulation to milk is considered. The shortcoming of prevalence views considering paracellular leakage as the most probable explanation is highlighted. A detailed discussion explaining why transcellular route is the most probable explanation for the presence of plasminogen in milk is presented.

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