کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4499906 1624008 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A two-phase model for drug release from microparticles with combined effects of solubilisation and recrystallisation
ترجمه فارسی عنوان
یک مدل دو فاز برای آزاد سازی دارو از میکروکاستیک با اثرات ترکیبی محلول سازی و کریستال شدن
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• A comprehensive two-phase mathematical model is developed for drug release from microparticle to the adjacent tissues.
• Drug release mechanism is governed by solubilisation dynamics of drug crystallites and its diffusion through the microparticle including reversible dissociation/recrystallisation processes.
• The results reveal that by altering the parameters, various means of drug release control can be achieved as per patient's need.
• Drug needs much longer time in the tissue to get absorbed completely (in comparison to the time required by drug in the microparticle to get released), as a result, its effect will persist for a long time before repetition of drug takes place.

The present study aims to provide a comprehensive mathematical model for drug release from microparticles to the adjacent tissues. In the elucidation of drug release mechanisms, the role of mathematical modelling has been depicted thereby facilitating the development of new therapeutic drug by a systematic approach, rather than expensive experimental trial-and-error methods. In order to study the whole process, a two-phase mathematical model describing the dynamics of drug transport in two coupled media is presented. Drug release is described taking into consideration both solubilisation dynamics of drug crystallites and diffusion of the solubilised drug through the microparticle. In the coupled media, reversible dissociation/recystallisation processes are taking place. The model has led to a system of partial differential equations that are solved analytically. The model points out the important roles played by the diffusion, mass-transfer and reaction parameters, which are the main architects behind drug kinetics across two layers. The dependence of drug masses on the main parameters is also analysed.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematical Biosciences - Volume 272, February 2016, Pages 24–33
نویسندگان
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