کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
466282 697819 2016 10 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
A multiscale modelling of bone ultrastructure elastic proprieties using finite elements simulation and neural network method
ترجمه فارسی عنوان
مدل سازی چند مقیاسی از خواص الاستیک فراساختار استخوان با استفاده از شبیه سازی عناصر محدود و روش شبکه های عصبی
کلمات کلیدی
فراساختار استخوان؛ مدل سازی چند مقیاسی؛ روش المان محدود؛ محاسبات شبکه عصبی؛خصوصیات الاستیک
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر علوم کامپیوتر (عمومی)
چکیده انگلیسی


• A novel hybrid multiscale hierachical approach of bone ultrastructure
• 3D finite elements models for mineralized collagen fibril and fibre
• Nanomechanical elastics properties of bone ultrastructure scales

Bone is a living material with a complex hierarchical structure which entails exceptional mechanical properties, including high fracture toughness, specific stiffness and strength. Bone tissue is essentially composed by two phases distributed in approximately 30–70%: an organic phase (mainly type I collagen and cells) and an inorganic phase (hydroxyapatite-HA-and water). The nanostructure of bone can be represented throughout three scale levels where different repetitive structural units or building blocks are found: at the first level, collagen molecules are arranged in a pentameric structure where mineral crystals grow in specific sites. This primary bone structure constitutes the mineralized collagen microfibril. A structural organization of inter-digitating microfibrils forms the mineralized collagen fibril which represents the second scale level. The third scale level corresponds to the mineralized collagen fibre which is composed by the binding of fibrils. The hierarchical nature of the bone tissue is largely responsible of their significant mechanical properties; consequently, this is a current outstanding research topic. Scarce works in literature correlates the elastic properties in the three scale levels at the bone nanoscale. The main goal of this work is to estimate the elastic properties of the bone tissue in a multiscale approach including a sensitivity analysis of the elastic behaviour at each length scale. This proposal is achieved by means of a novel hybrid multiscale modelling that involves neural network (NN) computations and finite elements method (FEM) analysis. The elastic properties are estimated using a neural network simulation that previously has been trained with the database results of the finite element models. In the results of this work, parametric analysis and averaged elastic constants for each length scale are provided. Likewise, the influence of the elastic constants of the tissue constituents is also depicted. Results highlight that intelligent numerical methods are powerful and accurate procedures to deal with the complex multiscale problem in the bone tissue with results in agreement with values found in literature for specific scale levels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computer Methods and Programs in Biomedicine - Volume 134, October 2016, Pages 69–78
نویسندگان
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