|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|4760279||1421973||2017||3 صفحه PDF||سفارش دهید||دانلود کنید|
- GHB has been implicated in cases of suspected surreptitious administration.
- GHB has been implicated in cases of drug-facilitated sexual assault.
- Endogenous GHB is detected in alcoholic and non-alcoholic beverages.
- Endogenous GHB do not reach pharmacologically active levels.
- Endogenous GHB must be considered in alleged drug-facilitated sexual assaults.
GHB has been implicated in many cases of suspected surreptitious administration with the purpose of increasing victim vulnerability to sexual assault. Low amounts of endogenous (or naturally occurring) GHB, which do not reach pharmacologically active levels, have been detected in alcoholic and non-alcoholic beverages. Due to the continued requirement to obtain data on the presence of endogenous GHB in various beverage types, GHB concentrations were measured in a series of non-alcoholic beverages.Tonic water and lemon flavoured tonic water beverages were analysed at 0, 24 and 96Â h after the bottle opening using gas chromatography coupled to tandem mass spectrometry (GC-MS/MS) on an Agilent 6890/7000C Triple Quadrupole. GHB was detected in all beverages at very low amounts ranging from 89 to 145Â ng/mL (0.089-0.145Â mg/L) and did not demonstrate a general trend of variation for concentration along the tested time span (96Â h). The presented data provide additional evidence for the endogenous nature of GHB in non-alcoholic beverages at very low concentrations, which are many orders of magnitude lower than those described to produce any pharmacological effect on the subject. However, when considering a case of alleged drug-facilitated sexual assault, a low level of GHB detected in a drink may be related both to a surreptitiously GHB administration with subsequent dilution for concealment or to the presence of endogenous GHB. On this basis, a comprehensive analysis of all the available information, including circumstantial data demonstrating possible attempts to conceal GHB administration and an assessment of levels of endogenous GHB in the suspected beverage type, is of the utmost importance for a proper interpretation of the toxicological results.
Journal: Forensic Science International - Volume 277, August 2017, Pages e36-e38