کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
4765703 1362360 2018 9 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Facile construction and biological imaging of cross-linked fluorescent organic nanoparticles with aggregation-induced emission feature through a catalyst-free azide-alkyne click reaction
کلمات کلیدی
Aggregation-induced emission; Fluorescent organic nanoparticles; Click chemistry; Biological imaging;
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Facile construction and biological imaging of cross-linked fluorescent organic nanoparticles with aggregation-induced emission feature through a catalyst-free azide-alkyne click reaction
چکیده انگلیسی

•Fluorescent organic nanoparticles with aggregation-induced emission feature.•Fluorescent organic nanoparticles were fabricated through click reaction.•The click reaction is facile, rapid and efficient.•These AIE-active FONs are promising for biological imaging.

The research in fluorescent organic nanoparticles (FONs) with aggregation-induced emission (AIE) feature shows an upward trend due to their outstanding optical properties and potential biomedical applications. In this work, a novel strategy has been developed for the first time through a catalyst-free azide-alkyne click reaction, which could directly conjugate azide containing polymers (PEGMA-AGE-N3) and alkyne terminating AIE dye (named as PhE-OE) under mild experimental conditions. The final PEGMA-AGE-PhE copolymers containing AIE-active dye could self-assemble into FONs with intense fluorescence owing to their AIE feature. These PEGMA-AGE-PhE FONs were characterized by a series of characterization techniques in details. The cell viability as well as cell uptake behavior of PEGMA-AGE-PhE FONs was also examined to evaluate their potential for biomedical applications. We demonstrated that the catalyst-free azide-alkyne click reaction is effective for fabrication of AIE-active FONs and these AIE-active FONs showed high water dispersity and AIE feature. Moreover, the PEGMA-AGE-PhE FONs also exhibited low cytotoxicity and great potential for biological imaging. Taken together, a facile catalyst-free azide-alkyne click reaction with high efficiency has been developed for the preparation of AIE-active FONs, which showed excellent physicochemical properties for biological imaging applications.

Graphical abstractThe fluorescent organic nanoparticles with aggregation-induced emission feature have been fabricated based on a novel and efficient catalyst-free azide-alkyne click reaction.Download high-res image (493KB)Download full-size image

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Dyes and Pigments - Volume 148, January 2018, Pages 52-60
نویسندگان
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