کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
4765725 1362360 2018 6 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Oxidized-morpholine dressing ratiometric fluorescent probe for specifically visualizing the intracellular glutathione
کلمات کلیدی
Ratiometric fluorescent probes; Glutathione detection; Oxidation-induced; Naphthalimide sulfonamide;
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Oxidized-morpholine dressing ratiometric fluorescent probe for specifically visualizing the intracellular glutathione
چکیده انگلیسی

•A ratiometric fluorescent probe Np-NSO2-NO was constructed and synthesized.•Np-NSO2-NO exhibited high selectivity towards glutathione.•Np-NSO2-NO was capable to visualize the intracellular glutathione with low cytotoxicity.

A naphthalimide-based ratiometric fluorescent probe for determining glutathione (GSH) was constructed by installing two oxidized morpholine (e.g. thiomorpholine-S-dioxide and morpholine-N-oxide) components on the “off-to-on” GSH probe. This probe displayed high selectivity towards GSH. As well, the bioimaging application confirmed that this probe was capable of acting as an indicator to monitor the intracellular GSH. Thus, this work provides a promising strategy to construct the ratiometric fluorescent probe.

Graphical abstractA ratiometric fluorescent probe was designed from a turn-on probe by a simple oxidative strategy, which could be capable of specifically responding intracellular glutathione.Download high-res image (210KB)Download full-size image

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Dyes and Pigments - Volume 148, January 2018, Pages 292-297
نویسندگان
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