|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|4765725||1362360||2018||6 صفحه PDF||ندارد||دانلود رایگان|
â¢A ratiometric fluorescent probe Np-NSO2-NO was constructed and synthesized.â¢Np-NSO2-NO exhibited high selectivity towards glutathione.â¢Np-NSO2-NO was capable to visualize the intracellular glutathione with low cytotoxicity.
A naphthalimide-based ratiometric fluorescent probe for determining glutathione (GSH) was constructed by installing two oxidized morpholine (e.g. thiomorpholine-S-dioxide and morpholine-N-oxide) components on the âoff-to-onâ GSH probe. This probe displayed high selectivity towards GSH. As well, the bioimaging application confirmed that this probe was capable of acting as an indicator to monitor the intracellular GSH. Thus, this work provides a promising strategy to construct the ratiometric fluorescent probe.
Graphical abstractA ratiometric fluorescent probe was designed from a turn-on probe by a simple oxidative strategy, which could be capable of specifically responding intracellular glutathione.Download high-res image (210KB)Download full-size image
Journal: Dyes and Pigments - Volume 148, January 2018, Pages 292-297