کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4909359 | 1362617 | 2017 | 9 صفحه PDF | دانلود رایگان |
Some new diorganoantimony(III) and triorganoantimony(V) compounds of Schiff bases derived from amino acids having the general formula Ph2Sb[OC(R)CHC(Râ²)NC(Y) COOH] [where R = CH3, Râ²Â = C6H5, Y = H2CH2(1), âHCH2C6H5(2); R = Râ²Â = C6H5, Y = H2CH2(3), HCH2C6H5(4)] have been synthesized by the reaction of Ph3Sb with RC (O) CHC(Râ²) NHC(Y) COOH in 1:1 M ratio. Whereas Ph3Sb[OC(R)CHC(Râ²)NC(Y) COOH]2 (where R = CH3, Râ²Â = C6H5, Y = H2CH2(5), R = Râ²Â = C6H5, Y = HCH2C6H5(6)) have been synthesized by the reactions of Ph3SbBr2 with Na [OC(R) CHC(Râ²)NC(Y) COOH] in 1:2 M ratio, respectively in anhydrous benzene. All these compounds have been characterized by elemental analyses and molecular weight measurement. Probable structures of these compounds have been proposed on the basis of spectral studies (I.R. 1H and 13C NMR). Schiff base (R = CH3 Râ²Â = C6H5, Y = H2CH2) and its corresponding organoantimony(III) and -antimony(V) compounds have been screened for antimicrobial, antioxidant and antiplatelet activities. These synthesized compounds can be used as new class of antimicrobial, antioxidant and antiplatelet agents with potential for clinical development.
Journal: Journal of Saudi Chemical Society - Volume 21, Issue 1, January 2017, Pages 67-75