|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|4914571||1362626||2018||8 صفحه PDF||ندارد||دانلود رایگان|
â¢Supercritical impregnation was applied for loading vitamin E into silicone hydrogel.â¢Loading of vitamin E in supercritical CO2 is more effective than that in liquid solution.â¢Supercritical impregnation achieves timolol maleate diffusion in vitamin E rich region.â¢Timolol maleate diffusivity in hydrogel is reduced significantly by loading vitamin E.
Supercritical CO2 impregnation was applied to loading of vitamin E into silicone hydrogel for development of controlled release system of timolol maleate, hydrophilic ocular drug for glaucoma. Vitamin E was loaded into the silicone hydrogel to reduce the diffusivity of timolol maleate. Supercritical impregnation accomplishes the large amount of loaded vitamin E into the silicone hydrogel at the low concentration in supercritical CO2 compared with that by ethanol liquid solution. The loading of vitamin E 0.49Â gÂ gâ1-hydrogel by the supercritical impregnation results in the significant reduction of the diffusivity of timolol maleate in the silicone hydrogel to 1.4Â ÃÂ 10â5Â mm2Â minâ1 much smaller than of that without vitamin E, 13Â ÃÂ 10â5Â mm2Â minâ1. The release system of timolol maleate in silicone hydrogel with the low diffusivity is obtained from the effective loading of vitamin into the silicone hydrogel using the supercritical impregnation.
Graphical abstractDownload high-res image (123KB)Download full-size image
Journal: The Journal of Supercritical Fluids - Volume 131, January 2018, Pages 11-18