|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|49269||46730||2016||3 صفحه PDF||سفارش دهید||دانلود کنید|
• A facile method for the synthesis of isoindolinones was developed.
• A broad scope of amine substrates was suitable for this process.
• Good to excellent yields (up to 97%) were achieved in most cases.
A facile and efficient approach for the synthesis of N-substituted 3-oxoisoindoline-1-carbonitrile derivatives has been developed, with a Sc(OTf)3-catalyzed three-component Strecker/Lactamization cascade reaction involving methyl 2-formylbenzoate, TMSCN and amines in ethanol at room temperature. Good to excellent yields for a broad scope of amine substrates were achieved.
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Journal: Catalysis Communications - Volume 74, 10 January 2016, Pages 119–121