کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4932754 1433532 2017 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Roadmap to Alzheimer's Biomarkers in the ClinicBiomarkers for the diagnosis of Alzheimer's disease in clinical practice: an Italian intersocietal roadmap
ترجمه فارسی عنوان
نقشه راه بیولوژیک آلزایمر در کلینیک بیومارکرها برای تشخیص بیماری آلزایمر در عمل بالینی: یک نقشه راه بین الملی ایتالیایی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی

Biomarkers of brain amyloidosis and neurodegeneration/synaptic dysfunction are featured in recent diagnostic criteria for Alzheimer's disease. Several gaps in our knowledge, however, need to be filled before they can be adopted clinically. The aim of this article is to describe a roadmap, developed by a multidisciplinary task force, to rationally implement biomarkers for Italian Memory Clinics. This roadmap is based on a framework comprising 5 sequential phases: identification of leads for potentially useful biomarkers; development of clinical assays for clinical disease; evaluation of detection of early stages; definition of operating characteristics in relevant populations; and estimation of reducing disease-associated mortality, morbidity, and disability. The roadmap was devised by identifying current evidence of validity, still missing evidence, and action needed to collect this missing evidence. With appropriate adaptation to local, country-specific circumstances, the roadmap can be translated to other countries.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 52, April 2017, Pages 119-131
نویسندگان
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