کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4933098 1433790 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oculomotricity and Neurological Soft Signs: Can we refine the endophenotype? A study in subjects belonging to the spectrum of schizophrenia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Oculomotricity and Neurological Soft Signs: Can we refine the endophenotype? A study in subjects belonging to the spectrum of schizophrenia
چکیده انگلیسی


- Patients with schizophrenia (SZ) made more catch-up and intrusive saccades in smooth pursuit eye movement (SPEM) and fixation task in gap condition (GFT) compared to controls and siblings.
- Ultra High Risk patients (UHR) differed from controls when the importance of Neurological Soft Signs (NSS) was considered.
- Patients with schizophrenia and NSS+ made more catch-up saccades in SPEM and intrusive saccades in GFT compared to SZ patients with NSS− and controls.

Alterations in eye tracking and motor impairments as well as Neurological Soft Signs (NSS) are frequently reported in patients with schizophrenia as well as in their relatives, and are proposed as endophenotype of the disease. This study investigated smooth pursuit eye movement and fixation task with distractors with a gap condition, two markers of inhibitory control mechanism, in 49 patients with schizophrenia, 24 ultra-high risk subjects, 41 full biological clinical siblings of patients and 48 controls. NSS were assessed as a marker of abnormal neurodevelopment. The results revealed more intrusive saccades respectively in smooth pursuit eye movement and in fixation task with distractors with a gap condition in patients, respect to controls and full siblings. Ultra high-risk participants with high NSS committed intrusive saccades compared to controls. Patients with schizophrenia with high NSS also displayed more of these abnormalities, compared to patients with schizophrenia with low NSS and controls. These findings highlight a global inhibitory control defect, and suggested that ultra-high risk subjects and patients with schizophrenia could share oculomotor abnormalities, especially when they express a high neurodevelopmental deviance. These oculomotor alterations might suggest that cerebral structures such as prefrontal and cerebellum could be involved in the expression of this vulnerability.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 256, October 2017, Pages 490-497
نویسندگان
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