Integrating machine learning with region-based active contour models in medical image segmentation

- Machine learning is integrated with region-based active contour models.
- A map of classification probability scores from machine learning algorithm is used.
- Two family of regularization functions are proposed and used to regularize the map.
- The region-based active contour model is applied on the regularized map.
- The accuracy, speed, and sensitivity to parameter tuning are improved.

Region-based active contour models are effective in segmenting images with poorly defined boundaries but often fail when applied to images containing intensity inhomogeneity. The traditional models utilize pixel intensity and are very sensitive to parameter tuning. On the other hand, machine learning algorithms are highly effective in handling inhomogeneities but often result in noise from misclassified pixels. In addition, there is no objective function. We propose a framework which integrates machine learning with a region-based active contour model. Classification probability scores from machine learning algorithm, which are regularized using a non-linear function, are used to replace the pixel intensity values during energy minimization. In our experiments, we integrate the k-nearest neighbours and the support vector machine with the Chan-Vese method and compare the results obtained with the traditional methods of Chan-Vese and Li et al. The proposed framework gives better accuracy and less sensitive to parameter tuning.

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