کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4982717 | 1454243 | 2018 | 10 صفحه PDF | دانلود رایگان |
- Amino acid-based P(acryloyl-6-aminocaproic acid) brushes were fabricated on polyisobutylene surface.
- PAACA brushes provided excellent anti-fouling property and sites for immobilizing concanavalin A.
- QCM-D proved that concanavalin A-coupled micro domains could further capture erythrocytes.
- This method developed a platform on commercial polyisobutylene surface via an amino acid-based polymer brushes.
Amino acid-based P(acryloyl-6-aminocaproic acid) (PAACA) brushes were fabricated on polyisobutylene (PIB) surface combined with plasma pre-treatment and UV-induced grafting polymerization to construct an antifouling and functional material. The hydrophilicity and hemocompatibility of PIB were largely improved by surface modification of AACA, which were confirmed by water contact angle and platelet adhesion, respectively. PAACA brushes were precisely located onto the surface of PIB to create a patterned PIB-g-PAACA structure, and then the carboxyl groups on PAACA was activated to immobilize functional protein-Concanavalin A (Con A). The obtained Con A-coupled microdomains could further capture erythrocytes. This method developed a platform on commercial PIB surface via amino acid-based polymer brushes which had a promising application in drug delivery and disease diagnosis.
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Journal: Colloids and Surfaces B: Biointerfaces - Volume 161, 1 January 2018, Pages 73-82