کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5009178 | 1462043 | 2017 | 8 صفحه PDF | دانلود رایگان |
- Novel fluorescent probes based on benzochalcone fluorophore were designed and synthesized.
- The probes FD-1 and FD-2 exhibited satisfactory selectivity and sensitivity for discrimination of H2O2.
- The probe FD-2 has faster response rate and higher sensitivity than FD-1.
- The probe FD-2 showed good imaging capability in living cells and tissues with low cytotoxicity.
Hydrogen peroxide (H2O2), a member of reactive oxygen species (ROS), usually acts as a significant oxidative stress marker in some diseases for its abnormal expression. Due to the merits of non-invasive and high selectivity, fluorescent probe has been proved to be an efficient method for H2O2 detection. Herein, we presented two novel boronate probes FD-1 and FD-2, in which the C-B bonds are well suitable for high selective detection of H2O2. Notably, these two probes were based on 4-hydroxybenzochalcone fluorophore, which exhibits excellent fluorescent properties through the intramolecular hydrogen bond. The results demonstrated that these two probes displayed satisfactory sensitivity and selectivity to H2O2, and probe FD-2 displayed faster response rate to H2O2 than FD-1. Importantly, FD-2 was successfully applied to image H2O2 in living cells and tissues, indicating probe FD-2 has great potential to monitor the H2O2 in biological system.
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Journal: Sensors and Actuators B: Chemical - Volume 248, September 2017, Pages 257-264