Gene detection: An essential process to precision medicine

- Design and synthesis of bola molecules with high water solubility and excellent optical properties.
- Compound 7 can self-assemble into well-organized nanoparticles in aqueous.
- Nanoprobe 7 was demonstrated as an excellent bioprobe for detection of HSA with high selectivity and sensitivity.
- Prove that nanoprobe 7 can specifically and sensitively detect HSA in blood samples.
- Provide a promising platform for designing biomolecular responsive smart nanomaterial.

Gene detection plays an important role in public health and consumer finances cause its prominent functions in precision medicine, pathogens detection and species identification. What's more, the announcement of Precision Medicine Initiative would strengthen its status further in many aspects. Therefore, rapid and simplified gene detection techniques are in urgent demand to meet the practical use. During the last decades, gene detection techniques have advanced considerably by integrating various strategies such as microassay, nanotechnologies and electrochemical methods. Herein, we summerized the recent innovations of gene detection methods based on the signal read-out modalities, and highlight those techniques with the potentials to realize Point-of-care (POC) tests. Additionally, gene detection principle, amplification strategies and their applications are also discussed.