کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5031361 1470933 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A new label-free electrochemical immunosensor based on dendritic core-shell AuPd@Au nanocrystals for highly sensitive detection of prostate specific antigen
ترجمه فارسی عنوان
یک ایمونسنسور الکتروشیمیایی بدون برچسب با استفاده از نانوکریستالهای AuPd @ Au هسته پوسته Dendritic core-AU برای تشخیص بسیار حساس آنتی ژن خاص پروستات
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


- Dendritic core-shell AuPd@Au NCs were prepared by a one-pot wet-chemical approach.
- Xanthine was used as the green growth-directing agent.
- The AuPd@Au NCs served as the carrier and catalyst for PSA and H2O2 reduction, respectively.
- The constructed immunosensor showed improved analytical performance for the detection of PSA.

Herein, bimetallic dendritic core-shell AuPd@Au nanocrystals (AuPd@Au NCs) were prepared by a simple one-pot aqueous method using xanthine as a green growth-directing agent. By virtue of the enhanced peak currents in the H2O2 reduction catalyzed by AuPd@Au NCs, a label-free immunosensor was constructed for the detection of prostate specific antigen (PSA). The immunosensor exhibited significantly improved analytical performance for the assay of PSA with wide linear range of 0.1-50 ng mL-1 and low detection limit of 0.078 ng mL-1 (S/N = 3), coupled with the improved stability, reproducibility and selectivity. It provides a promising platform for clinical research and diagnosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 99, 15 January 2018, Pages 458-463
نویسندگان
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