کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5032162 1471110 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Noradrenaline has opposing effects on the hydraulic conductance of arterial intima and media
ترجمه فارسی عنوان
نورآدرنالین تاثیرات متفاوتی بر هدایت هیدرولیکی آنمی و شیمیایی شریانی دارد
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی

The uptake of circulating macromolecules by the arterial intima is thought to be a key step in atherogenesis. Such transport is dominantly advective, so elucidating the mechanisms of water transport is important. The relation between vasoactive agents and water transport in the arterial wall is incompletely understood. Here we applied our recently-developed combination of computational and experimental methods to investigate the effects of noradrenaline (NA) on hydraulic conductance of the wall (Lp), medial extracellular matrix volume fraction (ϕECM) and medial permeability (K11) in the rat abdominal aorta. Experimentally, we found that physiological NA concentrations were sufficient to induce SMC contraction and produced significant decreases in Lp and increases in ϕECM. Simulation results based on 3D confocal images of the extracellular volume showed a corresponding increase in K11, attributed to the opening of the ECM. Conversion of permeabilities to layer-specific resistances revealed that although the total wall resistance increased, medial resistance decreased, suggesting an increase in intimal resistance upon application of NA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 54, 21 March 2017, Pages 4-10
نویسندگان
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